https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 A comparison of in vivo viral targeting systems identifies adeno-associated virus serotype 9 (AAV9) as an effective vector for genetic manipulation of Leydig cells in adult mice https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38049 Wed 28 Jul 2021 16:00:45 AEST ]]> Androgen receptor is dispensable for x-zone regression in the female adrenal but regulates post-partum corticosterone levels and protects cortex integrity https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45206 Cyp11a1-Cre to specifically ablate AR from the mouse adrenal cortex. Results show that AR-signaling is dispensable for adrenal gland development in females, and for X-zone regression during pregnancy, but is required to suppress elevation of corticosterone levels post-partum. Additionally, following disruption to adrenal AR, aberrant spindle cell development is observed in young adult females. These results demonstrate sexually dimorphic regulation of the adrenal X-zone by AR and point to dysfunctional adrenal androgen signaling as a possible mechanism in the early development of adrenal spindle cell hyperplasia.]]> Wed 26 Oct 2022 17:41:19 AEDT ]]> Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45093 Wed 26 Oct 2022 12:23:52 AEDT ]]> Androgen receptor signalling in the male adrenal facilitates X-zone regression, cell turnover and protects against adrenal degeneration during ageing https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36575 Tue 09 Jun 2020 11:47:41 AEST ]]> Human Adipose-derived pericytes display steroidogenic lineage potential in vitro and influence Leydig cell regeneration in vivo in rats https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44983 in vitro upregulated steroidogenic genes but did not fully induce LC differentiation. In vivo, no difference in LC-regeneration was noted between Sham and hAd-PSC-transplanted rats. Interestingly, Cyp17a1 expression increased in hAd-PSC-transplanted testes compared to intact vehicle controls and the luteinising hormone/testosterone ratio returned to Vehicle control levels which was not the case in EDS + Sham animals. Notably, hAd-PSCs were undetectable one-month after transplantation suggesting this effect is likely mediated via paracrine mechanisms during the initial stages of regeneration; either directly by interacting with regenerating LCs, or through indirect interactions with trophic macrophages.]]> Thu 27 Oct 2022 09:17:40 AEDT ]]> Leukemia inhibitory factor-receptor is dispensable for prenatal testis development but is required in sertoli cells for normal spermatogenesis in mice https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34486 Thu 27 Jan 2022 15:56:27 AEDT ]]> A young testicular microenvironment protects Leydig cells against age-related dysfunction in a mouse model of premature aging https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45503 Fri 28 Oct 2022 16:07:11 AEDT ]]> Relationship of transcriptional markers to Leydig cell number in the mouse testis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42192 Fri 19 Aug 2022 10:18:17 AEST ]]>